Azelnidipine (CAS 123524-52-7) Suppliers and Product Information

Azelnidipine is a dihydropyridine calcium channel blocker with antihypertensive activity. It is used for treating ischemic heart disease and cardiac remodeling after myocardial infarction. Azelnidipine has a slow onset profile and was marketed in Japan for the treatment of hypertension. It exhibits tight binding and slow onset, correlated with its high lipophilicity.

Frequently Asked Questions about Azelnidipine

What is Azelnidipine used for?

Azelnidipine is primarily used for treating hypertension (high blood pressure). It is also used in the treatment of ischemic heart disease and cardiac remodeling after myocardial infarction.

How does Azelnidipine work?

Azelnidipine is a L-type calcium channel blocker. It works by blocking calcium channels in blood vessels, causing them to relax and widen, which lowers blood pressure.

What are the unique features of Azelnidipine?

Azelnidipine has a slow onset profile and long-lasting effect. It causes minimal stimulation of the sympathetic nervous system despite its significant depressor effect. It also has a gradual onset of activity with sustained pharmacodynamic effect even after plasma levels drop.

What are the common side effects of Azelnidipine?

The most common side effects of Azelnidipine are facial flushing and headache, similar to other dihydropyridines. Unlike some other calcium channel blockers, it does not typically cause reflex tachycardia.

How is Azelnidipine administered?

Azelnidipine is typically dosed orally once daily. The usual dosage is 8-16 mg.