Dextromethorphan Hydrobromide Monohydrate (CAS 6700-34-1): Properties, Uses, and Supplier Information

Dextromethorphan Hydrobromide Monohydrate is an antitussive drug used as a cough suppressant. It is a synthetic *** ***og with strong antitussive effects but does not provoke opioid activity. The compound acts as a non-competitive, low-affinity NMDA receptor antagonist and also inhibits nicotinic receptors. It has potential applications in multimodal ***gesic therapies for acute and neuropathic pain.

This compound is also known by several synonyms, including DXM, D-Methorphan, and (9α,13α,14α)-3-methoxy-17-methyl-morphinan hydrobromide monohydrate.

Frequently Asked Questions about Dextromethorphan Hydrobromide Monohydrate

Q: What is the primary use of Dextromethorphan Hydrobromide Monohydrate?

A: Dextromethorphan Hydrobromide Monohydrate is primarily used as an antitussive drug, meaning it acts as a cough suppressant. It is widely used in over-the-counter cough medications due to its strong antitussive effects.

Q: Does Dextromethorphan Hydrobromide Monohydrate have opioid-like effects?

A: Despite its structural similarity to *** and codeine, Dextromethorphan Hydrobromide Monohydrate does not provoke opioid activity, which is characteristic of several other *** derivatives.

Q: What are the pharmacological actions of Dextromethorphan Hydrobromide Monohydrate?

A: Dextromethorphan Hydrobromide Monohydrate binds to and inhibits NMDA receptors (IC50 = 0.55 μM) and nicotinic receptors (IC50s = 0.7-3.9 μM). It also blocks receptor-gated and voltage-gated calcium channels (IC50 = 60 μM) and voltage-gated sodium channels (IC50 = 78 μM).

Q: Are there any potential therapeutic applications for Dextromethorphan Hydrobromide Monohydrate beyond cough suppression?

A: Yes, Dextromethorphan Hydrobromide Monohydrate has been used in multimodal ***gesic therapies for acute and neuropathic pain. It also shows anticonvulsive and neuroprotective properties.