Tolmetin Sodium (CAS 35711-34-3) Suppliers and Product Information

Tolmetin sodium is a non-steroidal anti-inflammatory drug (NSAID) used for its anti-inflammatory properties. It is the monosodium salt of tolmetin and is often used in the form of its dihydrate. Tolmetin sodium acts as an EC 1.14.99.1 (prostaglandin endoperoxide synthase) inhibitor.

Tolmetin sodium is rapidly absorbed orally, with peak plasma levels reached within the first hour of administration. It has a short plasma half-life of approximately 1 hour due to extensive first-pass metabolism. The drug is highly bound to plasma proteins (99%) and is primarily excreted in the urine.

Common side effects include gastrointestinal discomfort, abdominal pain, and nausea, although these appear to be less severe than those observed with aspirin. Central nervous system effects such as dizziness and drowsiness may also occur.

Frequently Asked Questions about Tolmetin Sodium

Q: What is the main use of Tolmetin Sodium?

A: Tolmetin Sodium is primarily used as a non-steroidal anti-inflammatory drug (NSAID) for its anti-inflammatory properties.

Q: How is Tolmetin Sodium absorbed in the body?

A: Tolmetin Sodium is rapidly and almost completely absorbed when administered orally, with peak plasma levels reached within the first hour of administration.

Q: What is the half-life of Tolmetin Sodium?

A: Tolmetin Sodium has a relatively short plasma half-life of approximately 1 hour due to extensive first-pass metabolism.

Q: Are there any common side effects associated with Tolmetin Sodium?

A: Common side effects include gastrointestinal discomfort, abdominal pain, and nausea. Central nervous system effects such as dizziness and drowsiness may also occur. However, these side effects appear to be less severe than those observed with aspirin.