Vonoprazan Fumarate (CAS 881681-01-2) Suppliers and Product Information

Vonoprazan fumarate is a potassium-competitive acid blocker (P-CAB) that inhibits gastric H⁺/K⁺ATPase with an IC₅₀ of 17 nM. It is used for treating acid-related gastrointestinal disorders and has a stronger acid inhibitory effect than proton pump inhibitors.

Frequently Asked Questions

Q: What are the main uses of Vonoprazan Fumarate?

A: Vonoprazan Fumarate is primarily used for the treatment of erosive esophagitis, gastric ulcers, duodenal ulcers, and Helicobacter pylori infections. It is a potassium-competitive acid blocker that provides strong and lasting inhibition of gastric acid secretion.

Q: How does Vonoprazan Fumarate compare to traditional proton pump inhibitors?

A: Compared to traditional irreversible proton pump inhibitors like omeprazole, Vonoprazan Fumarate has a faster onset of action, achieving maximum acid suppression on the first day of administration. It is also not affected by gastric acid damage when taken orally and can improve nighttime acid breakthrough.

Q: What are the storage recommendations for Vonoprazan Fumarate?

A: Vonoprazan Fumarate should be stored at 2-8°C in a refrigerator or at -20°C. It is air and light sensitive, so proper storage is crucial to prevent impurities from forming due to air oxidation or microbial metabolism.