Metildigoxin (CAS 30685-43-9): Properties, Uses, and Supplier Information

Metildigoxin is a semisynthetic digitalis glycoside and a cardiotonic methylated digoxin derivative. It is used as a cardiotonic agent and is obtained by the O-methylation of Digoxin. Metildigoxin belongs to the product categories of Carbohydrates & Derivatives, Intermediates & Fine Chemicals, Pharmaceuticals, and Steroids.

Frequently Asked Questions about Metildigoxin

Q: What is the primary use of Metildigoxin?

A: Metildigoxin is primarily used as a cardiotonic agent, which means it helps improve the strength and efficiency of heart contractions.

Q: How is Metildigoxin synthesized?

A: Metildigoxin is obtained by the O-methylation of Digoxin. The manufacturing process involves dissolving Digoxin in a mixture of dimethylformamide and dioxane, then adding strontium hydroxide and aluminum oxide. Methyl mesylate is then added dropwise, followed by several extraction and purification steps.

Q: What are the toxicity levels of Metildigoxin?

A: The LD50 (lethal dose for 50% of the test population) for Metildigoxin in rats and mice varies depending on the route of administration: 4.8-4.9 mg/kg (intravenous), 6.2-4.8 mg/kg (intraperitoneal), and 8.3-7.8 mg/kg (oral).