Lithocholic Acid (CAS 434-13-9) Suppliers and Product Information

Lithocholic acid is a monohydroxy secondary bile acid derived from chenodeoxycholic acid by bacterial action. It is used in biochemical and pharmaceutical research, particularly in studies related to cholestasis and bile acid homeostasis.

Frequently Asked Questions about Lithocholic Acid

Q: What are the main applications of lithocholic acid?

A: Lithocholic acid is primarily used in research related to bile acids, cholestasis, and liver function. It has been used to study the regulation of hepatic phospholipid and bile acid homeostasis, and as a TGR5 modulator.

Q: Is lithocholic acid toxic?

A: Yes, lithocholic acid is considered a toxic secondary bile acid. It can cause intrahepatic cholestasis and has tumor-promoting activity in vitro. When administered to rodents, it can lead to decreased bile flow and accumulation of bile constituents in the liver and blood.

Q: How should lithocholic acid be stored?

A: Lithocholic acid should be stored at room temperature in a well-sealed container, protected from light and moisture.

Q: What are some methods for purifying lithocholic acid?

A: Lithocholic acid can be purified by converting it to its sodium or potassium salt, filtering, washing with cold water, and then reacidifying. It can also be recrystallized from acetone, ethanol, or acetic acid.