Fasudil Hydrochloride (CAS 105628-07-7) Suppliers and Product Information

Fasudil Hydrochloride is a potent Rho kinase inhibitor and vasodilator. It is used in the treatment of cardiovascular and cerebrovascular diseases, particularly for improving symptoms of ischemic cerebrovascular disease such as cerebral vasospasm following subarachnoid hemorrhage. It has neuroprotective properties and can inhibit the proliferation of vascular smooth muscle cells.

Frequently Asked Questions about Fasudil Hydrochloride

Q: What are the main uses of Fasudil Hydrochloride?

A: Fasudil Hydrochloride is primarily used for treating cardiovascular and cerebrovascular diseases, particularly cerebral vasospasm following subarachnoid hemorrhage. It also has potential applications in acute ischemic stroke, sequelae of cerebral vascular diseases, and angina pectoris.

Q: How does Fasudil Hydrochloride work?

A: Fasudil Hydrochloride acts as a Rho kinase inhibitor. It relaxes blood vessels, reduces tension of endothelial cells, and improves microcirculation in brain tissue. It also protects nerves against apoptosis and promotes their regeneration.

Q: What are the potential side effects of Fasudil Hydrochloride?

A: Possible adverse reactions include intracranial hemorrhage, gastrointestinal bleeding, pulmonary hemorrhage, nasal bleeding, subcutaneous bleeding, loss of consciousness, abnormal liver function, low blood pressure, anemia, leukopenia, renal dysfunction, polyuria, rashes, and fever.

Q: Are there any precautions for using Fasudil Hydrochloride?

A: Fasudil Hydrochloride should not be used in patients with intracranial hemorrhage or low blood pressure. Caution is advised for patients with diabetes, cerebral arterial sclerosis, severe disturbance of consciousness, liver or kidney dysfunction, those over 70 years old, pregnant women, and children. It should only be administered via intravenous drip.