(tert-butyl)[beta-hydroxy-3,4-bis(p-toluoyloxy)phenethyl]ammonium methanesulphonate (CAS 30392-41-7) Suppliers and Product Information

Description: Bitolterol is a prodrug that releases colterol on activation by esterases in the lung. It is a β2-selective agonist with a binding potency equivalent to isoetharine and terbutaline. The ester form is lipophilic, which helps to keep it local in the lung and resistant to COMT, increasing its duration of action. Onset begins 2 to 4 minutes after administration, and the effect can last up to 8 hours.

Uses: β2 adrenergic receptor agonist, used for relief of bronchospasm in conditions such as asthma, chronic bronchitis, and emphysema.

Brand Name: Tornalate (Sanofi-Aventis)

Frequently Asked Questions

Q: What is the primary use of Bitolterol Mesylate?

A: Bitolterol Mesylate is primarily used as a β2 adrenergic receptor agonist for the relief of bronchospasm in conditions such as asthma, chronic bronchitis, and emphysema.

Q: How does Bitolterol Mesylate work?

A: Bitolterol is a prodrug that releases colterol when activated by esterases in the lung. As a β2-selective agonist, it helps to relax bronchial smooth muscle, providing relief from bronchospasm.

Q: What are the advantages of Bitolterol Mesylate compared to other β2 agonists?

A: Bitolterol Mesylate has a lipophilic ester form, which helps to keep it localized in the lung and resistant to COMT (Catechol-O-methyltransferase). This property tends to increase its duration of action, with effects lasting up to 8 hours. It also has a similar adverse effect profile to other β2-selective agonists but with less drowsiness and restlessness compared to other direct-acting agonists.

Q: How quickly does Bitolterol Mesylate take effect?

A: The onset of action for Bitolterol Mesylate begins 2 to 4 minutes after administration.