Methotrexate (CAS 59-05-2) Suppliers and Product Information

Methotrexate is a light yellow to yellow powder. It has a pKa of 3.04-4.99 and should be stored in a dark place, under an inert atmosphere, and in a freezer below -20°C. It is used for the treatment of cancer and rheumatoid arthritis.

Methotrexate acts as an inhibitor of dihydrofolate reductase (DHFR), with a Ki of 10^-11 M. This enzyme is crucial for maintaining biologically active folates in cells, which are essential for DNA synthesis and cell division.

Frequently Asked Questions about Methotrexate

Q: What is the primary use of Methotrexate?

A: Methotrexate is primarily used for the treatment of cancer and rheumatoid arthritis. It acts as an antimetabolite and antifolate, inhibiting the enzyme dihydrofolate reductase, which is crucial for DNA synthesis and cell division.

Q: How should Methotrexate be stored?

A: Methotrexate should be stored in a dark place, under an inert atmosphere, and in a freezer below -20°C to maintain its stability and efficacy.

Q: What is the solubility of Methotrexate?

A: Methotrexate is insoluble in water.

Q: Are there any precautions when handling Methotrexate?

A: Yes, Methotrexate should be handled with care. It is toxic by inhalation, in contact with skin, and if swallowed. It can also cause irritation to eyes, respiratory system, and skin. Additionally, it may cause cancer and heritable genetic damage.