Cilastatin (CAS 82009-34-5) Suppliers and Product Information

Cilastatin is an inhibitor of dipeptidase (dehydropeptidase I), a renal dipeptidase. It prevents renal metabolism of penem and carbapenem antibiotics by specific and reversible dehydropeptidase I inhibition. Cilastatin is used as an antibacterial adjunct, often in combination with imipenem to treat susceptible bacterial infections.

Frequently Asked Questions

Q: What is the primary use of Cilastatin?

A: Cilastatin is primarily used to prevent the renal metabolism of penem and carbapenem antibiotics, particularly imipenem. It acts as a specific and reversible inhibitor of dehydropeptidase I, an enzyme found in the kidney that is responsible for breaking down these antibiotics.

Q: How does Cilastatin work?

A: Cilastatin works by inhibiting renal dehydropeptidase-I and leukotriene D4 dipeptidase. This inhibition prevents the breakdown of certain antibiotics in the kidney, thereby prolonging their half-life and enhancing their effectiveness.

Q: What are some common formulations of Cilastatin?

A: Cilastatin is often formulated in combination with imipenem. This combination is used to treat susceptible bacterial infections, particularly those caused by polyresistant Gram-negative microorganisms and serious complex infections.

Q: What are the storage requirements for Cilastatin?

A: Cilastatin should be stored in a freezer under -20°C. It should be kept in a dark place and sealed in dry conditions to maintain its stability.