Herbimycin A (CAS 70563-58-5) Suppliers and Product Information

Herbimycin A is an ansamycin antibiotic that acts as a Src family kinase inhibitor. It binds to the SH domain and inhibits the activity of p60v-src and p210BCR-ABL. It exhibits antiangiogenic activity in endothelial cells in vitro and also inhibits Hsp90, impairing recovery from heat shock.

Herbimycin A is a cell-permeable inhibitor of protein tyrosine kinases, including c-Abl, HSP 90, c-Src, c-Yes, Fes, and Ros. It has been shown to induce apoptosis and display antitumor effects. It is also used in COVID-19 related research.

Frequently Asked Questions about Herbimycin A

Q: What is the primary mechanism of action of Herbimycin A?

A: Herbimycin A primarily acts as a Src family kinase inhibitor and an Hsp90 inhibitor. It binds to the SH domain of Src kinases and inhibits their activity, as well as destabilizing Hsp90 client proteins.

Q: What are some applications of Herbimycin A in research?

A: Herbimycin A is used in research related to cancer, angiogenesis, and signal transduction. It has been shown to inhibit oncogenic transformation, block angiogenesis, and affect various cellular processes involving tyrosine kinases and Hsp90.

Q: How should Herbimycin A be stored?

A: Herbimycin A should be stored at -20°C. It is stable for 2 years from the date of purchase when supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Q: Is Herbimycin A light-sensitive?

A: Yes, Herbimycin A is light-sensitive and hygroscopic. Proper storage and handling precautions should be taken to maintain its stability.