Desipramine Hydrochloride (CAS 58-28-6) Suppliers and Product Information

Desipramine hydrochloride is a tricyclic antidepressant and a selective inhibitor of noradrenalin transporters. It is used to treat depression and manage enuresis in children. The compound is also known by brand names such as Norpramin and Pertofrane.

Desipramine hydrochloride acts as an inhibitor of norepinephrine, serotonin, and dopamine transporters, with highest affinity for the norepinephrine transporter (NET). It has Ki values of 4 nM for NET, 61 nM for SERT, and 78,720 nM for DAT.

This compound is primarily used for research purposes and as a pharmaceutical reference standard. It is important to note that it is intended for laboratory use only and should be handled with appropriate safety precautions.

Frequently Asked Questions about Desipramine Hydrochloride

Q: What is the main use of desipramine hydrochloride?

A: Desipramine hydrochloride is primarily used as an antidepressant medication. It is also used to treat enuresis (bedwetting) in children and can help manage pain associated with diabetic neuropathy.

Q: How does desipramine hydrochloride work?

A: Desipramine hydrochloride works as a selective inhibitor of noradrenalin transporters. It is more potent at inhibiting the norepinephrine transporter than the serotonin transporter, which distinguishes it from some other tricyclic antidepressants.

Q: What precautions should be taken when handling desipramine hydrochloride?

A: Desipramine hydrochloride should be handled with care. It is toxic if ingested, and can cause decreased urine volume and changes in sodium and chlorine levels. It should be stored in a desiccator at 4°C. When heated to decomposition, it emits toxic fumes of NO and HCl.