Lumefantrine (CAS 82186-77-4) Suppliers and Product Information

Lumefantrine is an antimalarial drug used in combination with artemether for the treatment of multi-drug resistant strains of falciparum malaria. It has marked blood schizonticidal activity against a wide range of plasmodia, including chloroquine-resistant P. falciparum. The drug works by inhibiting the formation of β-hematin by forming a complex with hemin.

Frequently Asked Questions about Lumefantrine

Q: What is the main use of Lumefantrine?

A: Lumefantrine is primarily used as an antimalarial drug, especially in combination with artemether for treating multi-drug resistant strains of falciparum malaria.

Q: How is Lumefantrine administered?

A: Lumefantrine is typically administered orally. For ***s, a common dosage is 800mg at first, followed by 400mg daily for 3-4 days. Dosage for children is weight-based at 8mg/kg daily for 4 days, with the first dose doubled.

Q: What are the common side effects of Lumefantrine?

A: When used in combination with artemether, the most common adverse effects include headache, dizziness, and gastrointestinal disturbances. However, significant adverse reactions are rare.

Q: How does Lumefantrine work in the body?

A: While its exact mechanism of action is not fully understood, evidence suggests that Lumefantrine inhibits the formation of β-hematin by forming a complex with hemin, which is crucial for the parasite's survival.

Q: Are there any special precautions when using Lumefantrine?

A: Patients with heart or kidney dysfunction should use Lumefantrine with caution. It's also important to note that absorption is substantially increased when taken with food, particularly high-fat content meals.