Mesna (CAS 19767-45-4) Suppliers and Product Information

Mesna is used as an antioxidant and cytoprotective agent in various applications, including protection from toxicity of therapeutic agents such as cyclophosphamide and prevention of brain injury damage. It is also used as a mucolytic agent and as an antidote to chloro-acetyl-aldehyde and acrolein, which are bladder-toxic metabolites of ifosfamide or cyclophosphamide.

Frequently Asked Questions about Mesna

Q: What is the main use of Mesna?

A: Mesna is primarily used to protect the bladder wall from the harmful effects of some cancer-fighting drugs, particularly oxazaphosphorines like cyclophosphamide or ifosfamide. It reacts with acrolein and other urotoxic metabolites to form stable, non-urotoxic compounds.

Q: Does Mesna have any antitumor activity?

A: No, Mesna itself does not have any antitumor activity. It also does not appear to interfere with the antitumor activity of antineoplastic drugs.

Q: How is Mesna administered?

A: Mesna can be administered intravenously or orally. However, the oral solution has been associated with allergic reactions in some cases, leading to its withdrawal in certain markets.

Q: What are some brand names for Mesna?

A: Some brand names for Mesna include Ausobrone, Mesnex, Mistabronco, Mistalon, Mucofluid, Mucolene, Uromitexan, and Uronexitan.