Estazolam (CAS 29975-16-4): Properties, Uses, and Safety Information

Estazolam is a triazolobenzodiazepine medication used for the short-term treatment of insomnia. It possesses anxiolytic, anticonvulsant, hypnotic, sedative, and skeletal muscle relaxant properties. As an intermediate-acting oral benzodiazepine, estazolam exerts its therapeutic effects by acting as an agonist at benzodiazepine receptors.

Pharmacokinetics: Peak plasma levels are achieved within 1-6 hours. The elimination half-life averages 19 hours (range: 8-31 hours). Major metabolites include 4-hydroxyestazolam, 1-oxo-estazolam, and 4'-hydroxy-estazolam.

Safety: Estazolam is classified as a controlled substance due to its potential for dependence and abuse. Common adverse reactions include drowsiness, dizziness, fatigue, and unsteady gait. Long-term use may lead to tolerance, dependence, and withdrawal symptoms upon discontinuation.

Frequently Asked Questions about Estazolam

Q: What is the primary use of estazolam?

A: Estazolam is primarily used for the short-term treatment of insomnia.

Q: How does estazolam work?

A: Estazolam works by acting as an agonist at benzodiazepine receptors, enhancing the effects of GABA in the brain, which leads to sedation and other therapeutic effects.

Q: What are the potential side effects of estazolam?

A: Common side effects include drowsiness, dizziness, fatigue, and unsteady gait. More severe reactions may include headache, ataxia, motor dysfunction, slurred speech, and respiratory depression.

Q: Is estazolam safe for long-term use?

A: Long-term use of estazolam is not recommended due to the risk of tolerance, dependence, and withdrawal symptoms. It may also lead to adverse effects such as memory loss, cognitive impairment, and changes in libido.