Cephaeline (CAS 483-17-0) Suppliers and Product Information

Cephaeline is a pyridoisoquinoline alkaloid found in ipecac root. It has been used as an emetic and expectorant. The compound exhibits antimicrobial properties, with reported IC50 values against Plasmodium falciparum (59.36 nM) and Leishmania donovani (64.29 nM). It also shows cytotoxic activity against various human cancer cell lines.

Frequently Asked Questions

Q: What are the main uses of cephaeline?

A: Cephaeline has been used primarily as an emetic and expectorant. It also shows potential as an anti-amebic reagent and has demonstrated antimicrobial and cytotoxic properties in research settings.

Q: How should cephaeline be stored?

A: Cephaeline should be stored at -20°C. It is hygroscopic, so proper storage conditions are important to maintain its stability.

Q: What are the safety considerations when handling cephaeline?

A: Cephaeline is less toxic than emetine, but its effects are cumulative. High doses may cause hypotension, muscle weakness, and gastrointestinal problems including nausea, vomiting, and diarrhea. Proper safety precautions should be taken when handling this compound.