Asenapine (CAS 65576-45-6) Suppliers and Product Information

Asenapine is an atypical antipsychotic that binds to various receptors, including dopamine D1-4, α-adrenergic, histamine, and serotonin 5-HT receptor subtypes. It is used in the treatment of schizophrenia and bipolar I disorder. Asenapine inhibits neuron firing suppression induced by various receptor agonists and increases extracellular dopamine levels in specific brain regions.

Frequently Asked Questions about Asenapine

Q: What is the primary use of Asenapine?

A: Asenapine is primarily used as an atypical antipsychotic for the treatment of schizophrenia and bipolar I disorder.

Q: What are the main receptor targets of Asenapine?

A: Asenapine binds to dopamine D1-4, α-adrenergic, histamine, and various serotonin 5-HT receptor subtypes, including 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5A, 5-HT6, and 5-HT7.

Q: How is Asenapine metabolized?

A: Asenapine is metabolized primarily through direct glucuronidation by UGT1A4 and oxidative metabolism by cytochrome P450 isoenzymes, predominantly CYP1A2.

Q: What are the potential drug interactions with Asenapine?

A: Asenapine may interact with various drugs, including anesthetics, ***gesics, anti-arrhythmics, antidepressants, antiepileptics, antimalarials, antivirals, and anxiolytics. It's important to consult a healthcare professional for specific drug interaction information.