TICRYNAFEN Suppliers and Product Information

TICRYNAFEN, also known as Tienilic Acid, is a diuretic and hypertensive medication. It was originally marketed under the brand name Diflurex by Anphar in France in 1976, and later as Selacryn by SmithKline Beecham. The compound has a molecular formula of C13H8Cl2O4S and an uncertain pKa value of 2.7.

Frequently Asked Questions

Q: What is the main use of TICRYNAFEN?

A: TICRYNAFEN, also known as Tienilic Acid, is primarily used as a diuretic and hypertensive medication.

Q: How is TICRYNAFEN synthesized?

A: The synthesis of TICRYNAFEN involves a multi-step process: 1. Reaction of 2,3-dichloroanisole with thiophene-2-carboxylic acid chloride in the presence of aluminum chloride. 2. Treatment of the resulting ketone with aluminum chloride in benzene or methylene chloride. 3. Reaction of the phenol product with ethyl chloroacetate in the presence of sodium ethoxide, followed by hydrolysis to obtain the final acid.

Q: What are some alternative names for TICRYNAFEN?

A: TICRYNAFEN is also known by the following names: - Tienilic Acid (INN and BAN) - AKOS 91365 - Diflurex (original brand name) - Selacryn (later brand name)