DOXEPIN (CAS 1668-19-5) Suppliers and Product Information

DOXEPIN is a tricyclic antidepressant used to treat anxiety, depression, and insomnia. It is also used as a topical cream for treating itching. The compound belongs to the dibenzoxepin class and acts as a potent H1 histamine receptor antagonist. It is also known to bind to the H4 histamine receptor.

DOXEPIN is synthesized through a multi-step process involving the preparation of 3-bromopropyltriphenylphosphonium bromide, 3-dimethylaminopropyltriphenylphosphonium bromide hydrobromide, and finally, the reaction with 6,11-dihydrodibenz[b,e]oxepin-11-one to yield the final product.

Frequently Asked Questions about DOXEPIN

Q: What are the main uses of DOXEPIN?

A: DOXEPIN is primarily used to treat anxiety, depression, and insomnia. It is also used as a topical cream for treating itching.

Q: What is the mechanism of action of DOXEPIN?

A: DOXEPIN acts as a potent H1 histamine receptor antagonist and also binds to the H4 histamine receptor. It has antidepressant, anticholinergic, antihistamine, and anti-itching properties.

Q: Are there any safety concerns with DOXEPIN?

A: DOXEPIN can cause adverse effects, mainly due to its antimuscarinic actions. These include dry mouth, cardiac arrhythmias, central nervous system disturbances, blood disorders, and a risk of ***. Care should be taken with dosage due to the risk of overdose.

Q: Is DOXEPIN available in different forms?

A: Yes, DOXEPIN is available as oral medication for systemic effects and as a topical cream for localized anti-itching treatment.