Mianserin Hydrochloride (CAS 21535-47-7) Suppliers and Product Information

Mianserin hydrochloride is a tetracyclic antidepressant with an EEG and clinical activity profile similar to amitriptyline. It acts as an antagonist/inverse agonist at 5-HT2 serotonin receptors, blocks the H1 histamine receptor, and the α2 adrenoceptor. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.

Uses: Mianserin hydrochloride is used as an antidepressant. It may cause drowsiness and hematological problems. The compound is also used in research as a serotonin antagonist and antihistamine.

Frequently Asked Questions about Mianserin Hydrochloride

Q: What are the main therapeutic functions of Mianserin hydrochloride?

A: Mianserin hydrochloride functions primarily as a serotonin antagonist and antihistamine. It is used clinically as an antidepressant.

Q: How does Mianserin hydrochloride work in the body?

A: Mianserin hydrochloride acts as a non-selective 5-HT2 receptor antagonist, with Ki values of 0.0080 and 0.0081 μM for human 5-HT2A and 5-HT2C receptors, respectively. It also has moderate affinity for 5-HT6 receptors and blocks H1 histamine receptors and α2 adrenoceptors.

Q: Are there any significant drug interactions with Mianserin hydrochloride?

A: Yes, Mianserin hydrochloride has potentially hazardous interactions with several drugs. These include increased sedative effects with alcohol, interactions with certain antibacterials (avoid with linezolid and tedizolid), and interactions with other antidepressants (avoid with MAOIs and moclobemide). It may also interact with certain antiepileptics, antimalarials, and other medications. Always consult a healthcare professional for a complete list of drug interactions.

Q: How is Mianserin hydrochloride metabolized in the body?

A: Mianserin is hepatically metabolized via aromatic hydroxylation, N-oxidation, and N-demethylation. Three urinary metabolites have been identified: N-desmethyl, 8-hydroxy, and N-oxide derivatives. The desmethyl metabolite, which is also active, has similar pharmacokinetic behavior as the parent compound. Mianserin is excreted in the urine almost entirely as its metabolites, either free or in conjugated form, with 14-28% excreted in the feces.