Tigecycline (CAS 220620-09-7) Suppliers and Product Information

Tigecycline is a broad-spectrum glycylcycline antibiotic used to treat complex skin and skin structure infections, as well as complex abdominal infections. It is effective against various gram-positive, gram-negative, and anaerobic bacteria, including some drug-resistant strains.

Frequently Asked Questions about Tigecycline

What is Tigecycline used for?

Tigecycline is used to treat complex skin and skin structure infections, as well as complex abdominal infections in patients 18 years and older. It is particularly useful for treating infections caused by multi-drug resistant bacteria.

How does Tigecycline work?

Tigecycline binds to bacterial 30S ribosomes, preventing transfer RNA from entering. This inhibits protein synthesis and limits bacterial growth. Its binding ability is 5 times stronger than other tetracycline antibiotics, making it more effective against resistant bacteria.

What are the common side effects of Tigecycline?

The most common adverse effects are nausea and vomiting, which usually occur in the first 1-2 days of treatment and are mild to moderate in intensity. In clinical trials, about 35% of patients experienced nausea and 20% experienced vomiting.

How is Tigecycline administered?

Tigecycline is administered through intravenous injection. The specific dosage and duration of treatment depend on the type and severity of the infection, as well as the patient's condition.

Is Tigecycline effective against antibiotic-resistant bacteria?

Yes, Tigecycline is effective against many antibiotic-resistant bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). Its unique structure and mechanism of action make it less susceptible to common resistance mechanisms.