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Desipramine is a tricyclic antidepressant used to treat depression. It works by increasing levels of norepinephrine in the brain. Desipramine is metabolized primarily by CYP2D6 to its 2-hydroxy metabolite.

Frequently Asked Questions

Q: What is the mechanism of action of desipramine?

A: Desipramine's antidepressant effect results from increasing norepinephrine levels in CNS synapses. Long-term administration causes downregulation of α1-adrenoceptors and desensitization of presynaptic α2 receptors, equilibrating the noradrenergic system. It also downregulates the norepinephrine transporter (NET).

Q: How is desipramine synthesized?

A: Desipramine can be synthesized by alkylating 10,11-dihydro-5H-dibenz[b,f]azepine with 1-bromo-3-chloropropane, followed by reaction with methylamine. Alternatively, it can be made by demethylating imipramine.

Q: What are some brand names for desipramine?

A: Brand names for desipramine include Norpramin and Pertofrane, both manufactured by Sanofi-Aventis.