Fentanyl Citrate (CAS 990-73-8): Chemical Properties, Uses, and Safety Information

Fentanyl citrate is a potent opioid ***gesic used in the management of labor pain, postoperative pain, and chronic intractable cancer pain. It is a μ-opioid receptor agonist with high selectivity and potency. The compound is widely used as an ***gesic component in balanced anesthesia.

Safety Information: Fentanyl citrate is classified as toxic and highly hazardous. It carries risk statements including R26/27/28 (Very toxic by inhalation, in contact with skin and if swallowed) and R39/23/24/25 (Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed). Proper safety precautions must be taken when handling this compound.

Frequently Asked Questions about Fentanyl Citrate

Q: What is the primary use of fentanyl citrate?

A: Fentanyl citrate is primarily used as a potent opioid ***gesic for managing severe pain, including labor pain, postoperative pain, and chronic intractable cancer pain. It is also used as an ***gesic component in balanced anesthesia.

Q: How is fentanyl citrate administered?

A: Fentanyl citrate can be administered through various routes, including transdermal patches for chronic pain management (effective for up to 72 hours), lollipop form for oral cavity absorption, and parenteral (intravenous or subcutaneous) administration.

Q: What precautions should be taken when using fentanyl citrate?

A: Fentanyl citrate is a highly potent opioid and requires careful dosing. Elderly patients are usually more sensitive and require lower doses. Repeated doses can lead to accumulation and toxicities. It's crucial to follow prescribed dosages and medical supervision when using this medication.

Q: Are there any significant drug interactions with fentanyl citrate?

A: Yes, fentanyl citrate can interact with P-glycoprotein (P-gp) transported drugs. While it doesn't behave as a P-gp substrate, it can inhibit the P-gp-mediated efflux of other drugs, potentially increasing their blood levels. This can lead to important drug interactions, especially with medications like digoxin.