Roxatidine (CAS 78273-80-0) Suppliers and Product Information

Roxatidine is a novel histamine H2 receptor antagonist. It is clinically useful for prevention and healing of gastric and duodenal ulcers and bleeding. The compound suppresses inflammatory responses by inhibiting NF-κB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages. It also attenuates degradation of extracellular matrix in osteoarthritis models by inactivating the NF-κB pathway.

Frequently Asked Questions about Roxatidine

Q: What is the main use of Roxatidine?

A: Roxatidine is primarily used as a histamine H2 receptor antagonist for the prevention and treatment of gastric and duodenal ulcers and bleeding.

Q: How does Roxatidine work?

A: Roxatidine works by suppressing inflammatory responses through inhibition of NF-κB and p38 MAPK activation. It also attenuates degradation of extracellular matrix in osteoarthritis models by inactivating the NF-κB pathway.

Q: What is the recommended storage condition for Roxatidine?

A: Roxatidine is stable for 2 years from the date of purchase when stored as supplied. Solutions in DMSO can be stored at -20°C for up to 3 months.

Q: Is Roxatidine soluble in water?

A: The provided information doesn't specify water solubility. However, it is noted that Roxatidine is soluble in DMSO up to 25 mg/ml.