Saxagliptin (CAS 361442-04-8) Suppliers and Product Information

Saxagliptin is an oral hypoglycemic anti-diabetic drug of the dipeptidyl peptidase-4 (DPP-4) inhibitor class. It is used for the treatment of type 2 diabetes, either as monotherapy or in combination with other drugs. Saxagliptin works by inhibiting DPP-4, which increases the concentration of incretin hormones like GLP-1, leading to improved glucose regulation.

Frequently Asked Questions about Saxagliptin

Q: What is the primary use of Saxagliptin?

A: Saxagliptin is primarily used for the treatment of type 2 diabetes. It can be used as monotherapy or in combination with other anti-diabetic medications to improve glycemic control.

Q: How does Saxagliptin work?

A: Saxagliptin is a DPP-4 inhibitor. It works by inhibiting the enzyme DPP-4, which is responsible for breaking down incretin hormones like GLP-1. By preserving these hormones, Saxagliptin helps stimulate insulin production and reduce blood glucose levels.

Q: What are the common side effects of Saxagliptin?

A: The most common side effects of Saxagliptin include upper respiratory tract infections, urinary tract infections, and headaches. It may also cause allergic reactions such as rash and urticaria in some patients.

Q: Is there any risk associated with Saxagliptin use?

A: In 2016, the U.S. FDA added a warning about an increased risk of heart failure associated with Saxagliptin use. Studies have shown that it may increase the rate of hospitalization for heart failure by about 27%.

Q: How is Saxagliptin administered?

A: Saxagliptin is typically administered orally once daily. It has a pharmacokinetic profile that is compatible with once-daily dosing.