Cyclothiazide (CAS 2259-96-3) Suppliers and Product Information

Cyclothiazide is a positive allosteric modulator of AMPA receptors that potently inhibits AMPA receptor desensitization. It is selective for the flip variant of each of the four receptor subunits. Cyclothiazide has been used as a diuretic and antihypertensive agent clinically. It can induce epileptiform activity and seizures in animal models.

Frequently Asked Questions

Q: What is the main use of cyclothiazide?

A: Cyclothiazide is primarily used as a research tool to study AMPA receptor function. It acts as a positive allosteric modulator of AMPA receptors and inhibits their desensitization.

Q: How should cyclothiazide be stored?

A: Cyclothiazide should be stored at 2-8°C. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Q: What is the solubility of cyclothiazide?

A: Cyclothiazide is soluble in DMSO (up to 35 mg/ml) and ethanol (up to 9 mg/ml).