Kasugamycin Hydrochloride (CAS 19408-46-9) Suppliers and Product Information

Kasugamycin hydrochloride is an aminoglycosidic antibiotic isolated from Streptomyces kasugaensis. It inhibits protein synthesis by blocking the initiation of translation and preventing initiation complex formation on 30S ribosomes in bacteria. It is used as an antifungal agent, particularly for controlling rice blast disease caused by Pyricularia oryzae.

Frequently Asked Questions about Kasugamycin Hydrochloride

Q: What is the primary use of Kasugamycin hydrochloride?

A: Kasugamycin hydrochloride is primarily used as an antifungal agent in agriculture, particularly for controlling rice blast disease caused by Pyricularia oryzae. It is also used as an antibiotic that inhibits protein synthesis in bacteria.

Q: How does Kasugamycin hydrochloride work?

A: Kasugamycin hydrochloride works by inhibiting protein synthesis. It blocks the initiation of translation by interfering with the binding of aminoacyl-tRNA to the mRNA-30S ribosomal subunit complex. This mechanism is different from other aminoglycosides such as kanamycin, streptomycin, neomycin, and gentamicin.

Q: What is the stability of Kasugamycin hydrochloride?

A: Kasugamycin hydrochloride is relatively stable at room temperature. It is stable in weak acids but unstable in strong acids and under basic conditions. Its half-life (DT50) at 50°C is 47 days at pH 5 and 14 days at pH 9.

Q: How should Kasugamycin hydrochloride be stored?

A: Kasugamycin hydrochloride should be stored at 2-8°C, sealed in dry conditions. It is hygroscopic, so proper storage is important to maintain its stability.