Rubitecan (CAS 91421-42-0) Suppliers and Product Information

Rubitecan is a semisynthetic derivative of camptothecin and acts as a topoisomerase I inhibitor. It induces protein-linked DNA single-strand breaks, blocking DNA and RNA synthesis in dividing cells. This compound has shown potential as an oral treatment for various solid tumors, including melanoma, prostate, breast, and ovarian cancers, as well as leukemia.

Physical properties: - Appearance: Yellow amorphous powder - Melting point: 268-275°C - Optical rotation: 36.0° - Solubility: Soluble in DMSO, chloroform, and methanol

Rubitecan has demonstrated antitumor activity in preclinical studies, inhibiting the growth of various cancer cell lines, including ovarian, lung, and breast cancer cells. It has also shown efficacy in reducing tumor growth in animal models.

Frequently Asked Questions about Rubitecan

Q: What is the mechanism of action of Rubitecan? A: Rubitecan is a DNA topoisomerase I inhibitor. It works by inducing protein-linked DNA single-strand breaks, which block DNA and RNA synthesis in dividing cells. This mechanism is particularly effective in targeting rapidly dividing cancer cells.

Q: Is Rubitecan approved for clinical use? A: As of the current information available, Rubitecan (also known as Orathecin) has not been approved for clinical use. Its biological delivery mechanism is still not fully effective due to insolubility issues.

Q: What types of cancer has Rubitecan shown promise in treating? A: Rubitecan has shown potential as a treatment for various solid tumors, including melanoma, prostate, breast, and ovarian cancers. It has also demonstrated promise in treating leukemia.

Q: What are some alternative names for Rubitecan? A: Rubitecan is also known as RFS 2000, 9-Nitrocamptothecin, 9-NITRO-CPT, and Orathecin.

Q: How is Rubitecan typically administered? A: Rubitecan was developed as an oral treatment. However, due to its insolubility, the biological delivery mechanism is not yet fully effective, which has hindered its approval for clinical use.