Quetiapine (CAS 111974-69-7) Suppliers and Product Information

Quetiapine is a dibenzothiazepine antipsychotic medication used for treating schizophrenia, bipolar disorder, and major depressive disorder. It acts as a serotonergic, dopaminergic, and histamine antagonist. The compound is rapidly absorbed, with peak plasma levels occurring 1 to 2 hours after administration. It is 83% bound to plasma proteins and has a mean elimination half-life of 7 hours.

Frequently Asked Questions about Quetiapine

Q: What are the main uses of Quetiapine?

A: Quetiapine is primarily used to treat schizophrenia, mania in bipolar disorder, and depression in bipolar disorder.

Q: What are the common side effects of Quetiapine?

A: Common side effects include orthostatic hypotension and somnolence, likely due to adrenergic and histamine H1 receptor blockade, respectively.

Q: How is Quetiapine metabolized?

A: Quetiapine is extensively metabolized in the liver, primarily by the cytochrome P450 isoenzyme CYP3A4. The main metabolite is norquetiapine, which is also eliminated by CYP3A4.

Q: Are there any significant drug interactions with Quetiapine?

A: Yes, Quetiapine can interact with various drugs, including anaesthetics, ***gesics, anti-arrhythmics, antibacterials, antidepressants, antiepileptics, antifungals, and antivirals. It's important to consult with a healthcare professional about potential interactions.

Q: How does Quetiapine compare to typical antipsychotics?

A: Quetiapine is about as effective as haloperidol in treating positive symptoms of schizophrenia, but it also manages negative symptoms and induces a lower incidence of extrapyramidal side effects compared to typical antipsychotics.