Property | Value |
---|---|
Product Name | Cefazolin |
CAS Number | 25953-19-9 |
Molecular Formula | C14H14N8O4S3 |
Molecular Weight | 454.51 |
Melting Point | 198-200°C |
Appearance | White to Off-White Solid |
Purity | ≥99% |
Cefazolin is an antibacterial compound derived from 7-amino cephalosporanic acid. It is used as a systemic antibiotic and belongs to the first-generation cephalosporin class. Cefazolin has a thio-linked thiadiazole ring at C-3 and a tetrazoylmethylene unit at C-7, which contributes to its stability and longer half-life compared to some other cephalosporins.
Cefazolin is widely used in surgical prophylaxis, especially in biliary tract, orthopedic, cardiac, and gynecological surgeries. It is effective against many gram-positive and some gram-negative bacteria. However, it should be used with caution in patients with renal impairment, and dosing may need to be adjusted.
A: Cefazolin works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), which are enzymes involved in the final stage of peptidoglycan synthesis, leading to bacterial cell lysis and death.
A: Common side effects of Cefazolin include gastrointestinal disturbances, allergic reactions, and rarely, bleeding disorders. In some cases, it may cause neutropenia or hypoprothrombinemic bleeding. As with other cephalosporins, there is a risk of encephalopathy in patients with impaired excretion or when high CSF levels are reached.
A: Cefazolin is typically administered parenterally, either by intramuscular injection or intravenous infusion. The dosage and frequency depend on the type and severity of the infection, as well as the patient's renal function.
A: Cefazolin should be stored in a cool, dry place and protected from light. It is hygroscopic and may require storage under inert atmosphere. Proper personal protective equipment should be used when handling the compound, especially in its powder form.
Company Name | Contact | Product Details |
---|---|---|
Henan Tianfu Chemical Co., Ltd. | 86 0371 55170693, 86 19937530512 | Cefazolin vial 1g, Purity: 99%, Package: 25KG/5KG/1KG |
Xiamen AmoyChem Co., Ltd. | 86 592 6051114, 8618959220845 | Cefamezin (Cefazolin) |
Hubei widely chemical technology Co., Ltd. | 18627774460 | Cefazolin, Purity: 99%, Package: 4.5kg/Aluminum Hearing |
Hubei xin bonus chemical co., LTD. | 86 13657291602 | Cefazolin, Purity: 99%, Package: 5KG/1KG |
CONIER CHEM AND PHARMA LIMITED | 8618523575427 | Cefazolin, Purity: 99%, Package: 1kg |
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