Urapidil hydrochloride (CAS 64887-14-5) - α1-Adrenergic Antagonist and 5-HT1A Agonist

Urapidil hydrochloride is an α1-adrenergic receptor antagonist and a partial agonist of the serotonin 5-HT1A receptor. It has hypotensive properties and is used clinically as an antihypertensive agent. Urapidil selectively binds to α1 over α2 adrenergic receptors and to 5-HT1A over other serotonin receptor subtypes. It inhibits cAMP accumulation induced by forskolin in calf hippocampus and acts as a β1 adrenergic receptor antagonist.

Frequently Asked Questions

Q: What are the main pharmacological actions of urapidil hydrochloride?

A: Urapidil hydrochloride is primarily an α1-adrenergic receptor antagonist and a partial agonist of serotonin 5-HT1A receptors. It also has some β1-adrenergic antagonist activity.

Q: What is the clinical use of urapidil hydrochloride?

A: Urapidil hydrochloride is used clinically as an antihypertensive agent due to its ability to lower blood pressure.

Q: What are some potential side effects of urapidil hydrochloride?

A: Side effects that may occur during treatment with urapidil include dizziness, fatigue, nausea, and light-headedness. Some patients may experience a slight reduction in forced expiratory volume. Orthostatic hypotension is rare despite its α1-blocking action.

Q: How should urapidil hydrochloride be stored?

A: Urapidil hydrochloride should be stored at room temperature in a dark place under an inert atmosphere.