Azlocillin (CAS 37091-66-0) Suppliers and Product Information

Azlocillin is a semisynthetic penicillin antibiotic used for treating infections caused by Pseudomonas aeruginosa, Escherichia coli, and Haemophilus influenzae. It is highly effective against bacillus pyocyaneus, including strains resistant to carbenicillin and aminoglycosides. Azlocillin is used for various bacterial infections such as pyelonephritis, uretritis, cystitis, endometritis, cholecystitis, sepsis, peritonitis, endocarditis, meningitis, pneumonia, infections of the skin and soft tissues, and infected burns.

Frequently Asked Questions about Azlocillin

Q: What is the mechanism of action of Azlocillin?

A: Azlocillin, like other penicillins, works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) in the bacterial cell wall, disrupting the final stage of peptidoglycan synthesis, which leads to cell lysis and death of the bacteria.

Q: What is the spectrum of activity for Azlocillin?

A: Azlocillin has a broad spectrum of activity against both Gram-positive and Gram-negative aerobic and anaerobic microorganisms. It is particularly effective against Pseudomonas aeruginosa, including some strains resistant to other antibiotics. It also shows activity against Escherichia coli, Haemophilus influenzae, and various other bacterial species.

Q: How is Azlocillin administered?

A: Azlocillin is typically administered parenterally (by injection or infusion) as its sodium salt form. It is not available for oral administration due to poor oral bioavailability.

Q: Are there any notable side effects or precautions associated with Azlocillin use?

A: Like other penicillins, Azlocillin can cause allergic reactions in some patients. Common side effects may include gastrointestinal disturbances, skin rashes, and electrolyte imbalances. It should be used with caution in patients with a history of penicillin allergy. Additionally, as it can be hydrolyzed by most β-lactamases, its effectiveness may be reduced against β-lactamase-producing bacteria.