Cilnidipine (CAS 132203-70-4) Suppliers and Product Information

Cilnidipine is a dual L- and N-type calcium channel blocker used as an antihypertensive agent. It displays antihypertensive, sympatholytic, and neuroprotective activity. Cilnidipine lowers mean blood pressure and reduces cerebral vascular resistance without affecting cerebral blood flow.

Frequently Asked Questions about Cilnidipine

Q: What is the main use of Cilnidipine?

A: Cilnidipine is primarily used for the treatment of hypertension (high blood pressure). It is considered a "fourth generation" anti-hypertension drug, effective both in vivo and in vitro.

Q: How does Cilnidipine work?

A: Cilnidipine works by blocking both L-type and N-type calcium channels. This dual action allows it to dilate both arterioles and venules, reducing pressure in the capillary bed. It also attenuates platelet activation associated with catecholamines.

Q: What are the advantages of Cilnidipine over other calcium channel blockers?

A: Cilnidipine has a slow onset and long-term vasodilation effects, making it superior for long-term treatment compared to drugs like nifedipine and nicardipine. It also has less cardiodepressant activity and is well-tolerated with low toxicity.

Q: What is the typical purity of commercially available Cilnidipine?

A: Most suppliers offer Cilnidipine with a purity of ≥98%, with many providing 99% purity.