Indeloxazine (CAS 60929-23-9) Suppliers and Product Information

Indeloxazine is an antidepressant and cerebral activator that was previously marketed in Japan and South Korea. It acts as a serotonin releasing agent, norepinephrine reuptake inhibitor, and NMDA receptor antagonist. The compound has shown nootropic, neuroprotective, anticonvulsant, and antidepressant-like effects in animal models.

Frequently Asked Questions about Indeloxazine

Q: What was Indeloxazine used for?

A: Indeloxazine was used for the treatment of psychiatric symptoms associated with cerebrovascular diseases, particularly depression resulting from stroke, emotional disturbance, and avolition.

Q: Is Indeloxazine still available on the market?

A: No, Indeloxazine was marketed from 1988 to 1998 but was removed from the market reportedly due to lack of effectiveness.

Q: What are the main mechanisms of action of Indeloxazine?

A: Indeloxazine acts as a serotonin releasing agent, norepinephrine reuptake inhibitor, and NMDA receptor antagonist. It has also been found to enhance acetylcholine release in the rat forebrain through activation of the 5-HT4 receptor.

Q: What forms of Indeloxazine are available for research purposes?

A: Indeloxazine is available as a free base (CAS: 60929-23-9) and as a hydrochloride salt (CAS: 65043-22-3) for research purposes.