Guanabenz Acetate (CAS 23256-50-0) Suppliers and Product Information

Guanabenz Acetate is a cell-permeable α2-adrenoceptor agonist that lowers protein misfolding in stressed cells and acts as a proteostasis regulator. It is also known as an antihypertensive agent and has roles as a geroprotector. The compound is used in research and pharmaceutical applications.

Frequently Asked Questions about Guanabenz Acetate

Q: What are the main uses of Guanabenz Acetate?

A: Guanabenz Acetate is primarily used as an antihypertensive agent. It is a central α2-adrenergic agonist that reduces the release of norepinephrine from neurons, resulting in decreased sympathetic tone in the heart, kidneys, and peripheral blood vessels. It is also used in research for its effects on protein misfolding and as a proteostasis regulator.

Q: What are the pharmacokinetics of Guanabenz Acetate?

A: Guanabenz Acetate has an oral bioavailability of 70-80%. Its hypotensive effect begins within 1 hour, peaks in 2-7 hours, and diminishes within 6-8 hours. The elimination half-life averages 4-14 hours. It is approximately 90% bound to plasma proteins and is metabolized primarily by hydroxylation to its inactive metabolite 4-hydroxyguanabenz.

Q: Are there any side effects associated with Guanabenz Acetate?

A: While the frequency of adverse effects is similar to other α2-adrenergic agonists, the incidence is generally lower. As with other centrally active sympatholytics, abrupt withdrawal may result in rebound hypertension, but the withdrawal syndrome symptoms appear to be less severe compared to similar drugs.