Dantrolene Sodium (CAS 24868-20-0) Suppliers and Product Information

Dantrolene sodium is a skeletal muscle relaxant used in the treatment of malignant hyperthermia and spasticity. It acts by blocking calcium release from the sarcoplasmic reticulum, uncoupling excitation from contraction in muscle cells.

Therapeutic uses include: - Treatment of chronic severe spasticity of skeletal muscle (oral) - Treatment of malignant hyperthermia (IV) - Management of neuroleptic malignant syndrome

Side effects may include muscle weakness, drowsiness, dizziness, and in rare cases, hepatotoxicity.

Frequently Asked Questions

Q: What is the main use of dantrolene sodium?

A: Dantrolene sodium is primarily used as a skeletal muscle relaxant. It is most commonly used for treating and preventing malignant hyperthermia, a rare but life-threatening condition triggered by certain anesthetics. It's also used to manage chronic spasticity from conditions like multiple sclerosis, spinal cord injuries, or cerebral palsy.

Q: How does dantrolene sodium work?

A: Dantrolene sodium works by blocking the release of calcium from the sarcoplasmic reticulum in muscle cells. This action uncouples the excitation-contraction process in muscles, leading to muscle relaxation.

Q: What are the potential side effects of dantrolene sodium?

A: Common side effects include muscle weakness, drowsiness, dizziness, fatigue, and diarrhea. In rare cases, it can cause serious liver problems. Regular liver function tests are recommended for patients on long-term dantrolene therapy.