Property | Information |
---|---|
Product Name | Idarubicin |
CAS Number | 58957-92-9 |
Molecular Formula | C26H27NO9 |
Molecular Weight | 497.49 |
EINECS | 261-624-1 |
Category | Active Pharmaceutical Ingredients |
Idarubicin is an anthracycline antineoplastic agent used in the treatment of various cancers. It differs from its parent compound daunorubicin by the absence of the methoxy group in the anthracycline ring structure. Idarubicin is more lipophilic and potent than other anthracyclines like doxorubicin and daunorubicin.
Chemical Properties: - Boiling point: 589.46°C (rough estimate) - Density: 1.3477 (rough estimate) - Refractive index: 1.6000 (estimate) - Storage: Keep in dark place, sealed in dry, 2-8°C - Form: Solid - pKa: 4.73 ± 0.21 (Uncertain)
Safety Information: - Hazard Codes: T - Risk Statements: 60, 61, 28, 40 - Safety Statements: 53, 45 - WGK Germany: 3 - RTECS: HB7877000
Q: What is the primary use of Idarubicin? A: Idarubicin is primarily used as an antineoplastic agent in the treatment of various cancers. It is an anthracycline antibiotic that interferes with DNA synthesis and has shown effectiveness in treating certain types of leukemias and other malignancies.
Q: How does Idarubicin differ from other anthracyclines? A: Idarubicin differs from its parent compound daunorubicin by the absence of the methoxy group in the anthracycline ring structure. It is more lipophilic and more potent than other anthracyclines like doxorubicin and daunorubicin, which may contribute to its effectiveness in certain cancer treatments.
Q: What are the main mechanisms of action for Idarubicin? A: Idarubicin's mechanisms of action are similar to those of doxorubicin and daunorubicin. It interferes with DNA synthesis, inhibits topoisomerase II, and generates free radicals that can damage cellular components. Its increased lipophilicity may enhance its cellular uptake and distribution.
Q: What are the common adverse reactions associated with Idarubicin? A: Adverse reactions of Idarubicin are similar to those of its congeners (other anthracyclines). These may include myelosuppression, cardiotoxicity, nausea, vomiting, and alopecia. However, the specific side effect profile may vary, and patients should be monitored closely during treatment.
Q: How is Idarubicin metabolized and eliminated from the body? A: Idarubicin undergoes extensive hepatic metabolism and biliary excretion. Its primary metabolite, idarubicinol, is also active and contributes to the drug's overall effects. The drug and its metabolites are primarily eliminated through the liver and biliary system.
Company Name | Contact | Product Details |
---|---|---|
Shaanxi TNJONE Pharmaceutical Co., Ltd. | Tel: 8618740459177 | Purity: 99%, Package: 1kg |
Nanjing Finetech Chemical Co., Ltd. | Tel: 025-85710122, 17714198479 | Purity: 99% min, Package: 1KG, 10KG, 100KG, 500KG, 100g, ISO certified |
Hubei Jusheng Technology Co Ltd. | Tel: 18871490254 | Purity: 99%, Package: 5KG, 1KG, Formula: C26H27NO9 |
Hubei xin bonus chemical co., LTD. | Tel: 86 13657291602 | Purity: 0.99, Package: 5KG, 1KG |
Career Henan Chemical Co. | Tel: 86 0371 86658258, 8613203830695 | Purity: 95-99%, Package: 1KG, 1USD |
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