Celiprolol Hydrochloride (CAS 57470-78-7) Suppliers and Product Information

Celiprolol hydrochloride is a cardioselective β1-adrenergic antagonist with partial β2 agonist activity. It is used as an antihypertensive and antianginal agent. The compound is also being evaluated for use in glaucoma treatment.

Celiprolol hydrochloride is a once-daily cardioselective β-adrenergic blocker useful in the management of hypertension, angina pectoris, and hyperkinetic heart syndrome. It has minimal metabolism and is mainly excreted unchanged in urine (50%) and feces (50%).

Frequently Asked Questions about Celiprolol Hydrochloride

Q: What is the primary use of Celiprolol hydrochloride?

A: Celiprolol hydrochloride is primarily used as an antihypertensive and antianginal agent. It is a cardioselective β1-adrenergic antagonist that helps in managing hypertension, angina pectoris, and hyperkinetic heart syndrome.

Q: How does Celiprolol hydrochloride work?

A: Celiprolol hydrochloride works as a selective β1-adrenergic receptor blocker with partial β2 agonist activity. This dual action allows it to reduce blood pressure and heart rate while maintaining some bronchodilatory effects.

Q: What are the potential drug interactions with Celiprolol hydrochloride?

A: Celiprolol hydrochloride may interact with various drugs, including anesthetics, NSAIDs, anti-arrhythmics, antidepressants, other antihypertensives, antimalarials, antipsychotics, calcium channel blockers, diuretics, and sympathomimetics. These interactions can lead to enhanced hypotensive effects, increased risk of bradycardia, or other cardiovascular effects.

Q: How is Celiprolol hydrochloride metabolized and excreted?

A: Celiprolol hydrochloride undergoes minimal metabolism in the body. It is mainly excreted unchanged, with approximately 50% eliminated in the urine and 50% in the feces.