Thiopental Sodium (CAS 71-73-8) Suppliers and Product Information

Thiopental sodium is a short-acting barbiturate general anesthetic used for induction of anesthesia and brief surgical procedures. It is typically administered intravenously and has a rapid onset of action (30-45 seconds). The anesthetic effect is due to initial distribution to the brain, followed by redistribution to other tissues, primarily body fat.

This compound is often supplied as a mixture of approximately 100 parts sodium thiopental and 6 parts sodium carbonate (buffer salt). Solutions are alkaline (pH range of 10.2-11.2 for an 8% solution) and may decompose upon standing. The powdered product is hygroscopic and should be stored desiccated at room temperature.

Frequently Asked Questions about Thiopental Sodium

Q: What is the primary use of thiopental sodium?

A: Thiopental sodium is primarily used as a rapid-onset, short-acting barbiturate general anesthetic. It is commonly used for the induction phase of general anesthesia and for brief surgical procedures.

Q: How quickly does thiopental sodium take effect?

A: Following intravenous injection, thiopental sodium rapidly reaches the brain and causes unconsciousness within 30-45 seconds.

Q: Is thiopental sodium used for maintaining anesthesia during long surgeries?

A: No, thiopental sodium is not typically used to maintain anesthesia in surgical procedures. This is because it displays zero-order elimination pharmacokinetics when infused, leading to a long period before consciousness is regained. Instead, anesthesia is usually maintained with an inhaled anesthetic agent.

Q: What are some common side effects or risks associated with thiopental sodium?

A: Thiopental sodium may cause respiratory depression and decrease in body temperature. It is also an experimental teratogen and can have experimental reproductive effects. When heated to decomposition, it emits toxic fumes of NO and Na2O.

Q: Is thiopental sodium still widely used?

A: While thiopental sodium was once widely used, its use has been largely replaced with that of propofol in many countries. However, it may still retain some popularity as an induction agent for rapid-sequence induction and intubation, such as in obstetrics.