Clomipramine (CAS 303-49-1) Suppliers and Product Information

Clomipramine is a tricyclic antidepressant used for treating depression, obsessive-compulsive disorder, and phobias. It acts primarily as a serotonin reuptake inhibitor but also affects norepinephrine reuptake. The drug is well-absorbed orally with about 50% bioavailability and is metabolized primarily by CYP2D6 to its active metabolite N-desmethylclomipramine.

Frequently Asked Questions about Clomipramine

What is the main use of Clomipramine?

Clomipramine is primarily used as an antidepressant and for treating obsessive-compulsive disorder (OCD). It's considered one of the most potent antidepressants and is particularly effective for OCD.

How does Clomipramine work?

Clomipramine works by inhibiting the reuptake of serotonin and, to a lesser extent, norepinephrine in the brain. This action increases the concentration of these neurotransmitters, which helps alleviate symptoms of depression and OCD.

What are the common side effects of Clomipramine?

Common side effects include sexual dysfunction (particularly in males), dry mouth, constipation, dizziness, and drowsiness. Sexual side effects are dose-related and may be managed by adjusting the dosage.

Is Clomipramine safe during pregnancy?

Clomipramine crosses the placenta and is distributed into breast milk. Pregnant women or those planning to become pregnant should consult their healthcare provider before using this medication.