Radicicol (CAS 12772-57-5) Suppliers and Product Information

Radicicol is an antifungal antibiotic that inhibits heat shock protein 90 (Hsp90) activity by binding to its ATP-binding pocket. It suppresses cell transformation induced by src, ras, and mos oncogenes, represses estrogen receptor transcriptional activity, and inhibits angiogenesis. Radicicol also inhibits protein tyrosine kinase and has been shown to have antitumor properties.

Frequently Asked Questions about Radicicol

Q: What is the primary mechanism of action for Radicicol?

A: Radicicol primarily acts as an inhibitor of heat shock protein 90 (Hsp90) by binding to its ATP-binding pocket, which leads to the destabilization and degradation of Hsp90 client proteins.

Q: What are some potential applications of Radicicol?

A: Radicicol has potential applications in cancer research due to its ability to inhibit Hsp90, suppress oncogene-induced cell transformation, and inhibit angiogenesis. It may also be useful in studying cellular stress responses and protein folding mechanisms.

Q: How should Radicicol be stored?

A: Radicicol should be stored at -20°C for up to 1 month when dissolved in DMSO or ethanol. In its solid form, it is stable for up to 2 years when stored properly.