Isepamicine (CAS 58152-03-7) Suppliers and Product Information

Isepamicine is an aminoglycoside antibiotic used for treating urinary and respiratory tract infections. It has broad-spectrum activity comparable to amikacin, with enhanced effectiveness against certain bacterial strains. Isepamicine is less nephrotoxic than most other aminoglycosides, making it a valuable alternative in some clinical situations.

Frequently Asked Questions about Isepamicine

Q: What are the main clinical uses of Isepamicine?

A: Isepamicine is primarily used to treat respiratory tract infections, urinary tract infections, and intra-abdominal infections in both ***s and children. Its effectiveness is comparable to amikacin, with generally good tolerability.

Q: How does Isepamicine compare to other aminoglycosides?

A: Isepamicine is less potent than most other aminoglycosides but also less nephrotoxic. It has broader spectrum activity, particularly against Serratia marcescens, Enterobacter species, and Klebsiella pneumoniae. It also retains activity against some strains resistant to other aminoglycosides.

Q: What is the recommended dosage for Isepamicine?

A: For children less than 16 days old, a 7.5 mg/kg once-daily dosage is recommended. Adult dosing is similar to other aminoglycosides, but may need adjustment based on renal function. Elderly patients typically do not require dosage adjustment unless renal function is impaired.