Benazepril Hydrochloride (CAS 86541-74-4) Suppliers and Product Information

Benazepril hydrochloride is a long-acting angiotensin-converting enzyme (ACE) inhibitor used to treat hypertension. It is a prodrug that is converted to the active metabolite benazeprilat by hepatic cleavage. It works by reducing levels of chemicals that cause blood vessels to constrict, allowing for smoother blood flow. Benazepril hydrochloride is used alone or in combination with other medications to treat high blood pressure, congestive heart failure, and chronic kidney disease in both human and veterinary medicine.

Frequently Asked Questions

Q: What is the mechanism of action of benazepril hydrochloride?

A: Benazepril hydrochloride inhibits the activity of angiotensin-converting enzyme (ACE), blocking the conversion of angiotensin I to angiotensin II. This alleviates symptoms caused by angiotensin such as elevated blood pressure and increased heart rate.

Q: How is benazepril hydrochloride synthesized?

A: Benazepril hydrochloride is synthesized through a multi-step process involving asymmetric catalytic hydrogenation, nucleophilic substitution, and salt hydrolysis. Key steps include the preparation of (R)-ethyl 2-hydroxy-4-phenylbutyrate and its reaction with (3S)-3-amino-2,3,4,5-tetrahydro-2-oxo-1H-benzazepine-1-tert-butyl acetate.

Q: What are the main uses of benazepril hydrochloride?

A: Benazepril hydrochloride is primarily used to treat hypertension (high blood pressure). It is also used in the treatment of congestive heart failure and chronic kidney disease in both humans and animals.