Hydrocortisone Sodium Succinate Suppliers and Product Information

Hydrocortisone sodium succinate is a derivative of the glucocorticoid Hydrocortisone. It is used as an anti-inflammatory agent and is widely used in the treatment of asthma, endocrine disorders, dermatological disorders, and allergic states. It can bind to glucocorticoid receptors, initiating the transcription of anti-inflammatory and immunosuppressive mediators and inhibiting proinflammatory cytokine activity. It is commonly used to supplement media for long-term epithelial or endothelial cell cultures and to differentiate pluripotent stem cells.

Frequently Asked Questions

Q: What are the common brand names for Hydrocortisone Sodium Succinate?

A: Common brand names include A-Hydrocort (Abbott), A-Hydrocort (Hospira), and Solu-Cortef (Pharmacia & Upjohn).

Q: What are the potential drug interactions with Hydrocortisone Sodium Succinate?

A: Hydrocortisone Sodium Succinate may interact with several drugs, including: - Aldesleukin (avoid concomitant use) - Antibacterials (e.g., rifampicin, erythromycin, isoniazid) - Anticoagulants (e.g., coumarins, phenindione) - Antiepileptics (e.g., carbamazepine, fosphenytoin, phenobarbital, phenytoin, primidone) - Antifungals (e.g., amphotericin, itraconazole, ketoconazole) - Antivirals (e.g., ritonavir) - Ciclosporin - Cobicistat - Diuretics (e.g., acetazolamide, loop diuretics, thiazide diuretics) - Vaccines (avoid concomitant use with live vaccines)

Q: How is Hydrocortisone Sodium Succinate metabolized?

A: Hydrocortisone is metabolized in the liver and most body tissues to hydrogenated and degraded forms such as tetrahydrocortisone and tetrahydrocortisol. These are excreted in the urine, mainly conjugated as glucuronides, with a very small proportion of unchanged hydrocortisone.