Propafenone Hydrochloride (CAS 34183-22-7) Suppliers and Product Information

Propafenone Hydrochloride is a class IC antiarrhythmic agent used for the management of severe ventricular and supraventricular arrhythmias. It has beta-blocking and weak calcium channel blocking properties, as well as some negative inotropic activity. It works by acting on the heart muscle to improve the heart's rhythm.

Frequently Asked Questions about Propafenone Hydrochloride

Q: What is the main use of Propafenone Hydrochloride?

A: Propafenone Hydrochloride is primarily used as an antiarrhythmic agent for treating ventricular arrhythmias and paroxysmal supraventricular tachyarrhythmias, including paroxysmal atrial flutter or fibrillation.

Q: How does Propafenone Hydrochloride work?

A: Propafenone Hydrochloride works by reducing the fast inward sodium current in Purkinje fibers and myocardial fibers. It also has mild beta-blocking effects and calcium channel blocking effects, which contribute to its overall impact on the heart's conduction system.

Q: Are there any significant drug interactions with Propafenone Hydrochloride?

A: Yes, Propafenone Hydrochloride has several potential drug interactions. It may interact with other antiarrhythmics, antibacterials, anticoagulants, antidepressants, antihistamines, antipsychotics, antivirals, beta-blockers, cardiac glycosides, ciclosporin, and ulcer-healing drugs. It's important to consult with a healthcare professional about potential interactions.

Q: How is Propafenone Hydrochloride metabolized?

A: Propafenone Hydrochloride is primarily metabolized in the liver by the CYP2D6 enzyme, with minor contributions from CYP1A2 and CYP3A4. It forms two active metabolites (5-hydroxypropafenone and N-depropylpropafenone) and some inactive ones. The extent of metabolism is genetically determined.