Product Name | Esterified Estrogens |
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Synonyms | Esterified Estrogens |
CAS Number | Not provided |
Molecular Formula | Not provided |
Molecular Weight | Not provided |
Esterified estrogens is a mixture of sodium salts of sulfate esters of estrogenic substances, principally estrone. It contains 75-85% sodium estrone sulfate and 6-15% sodium equilin sulfate, with the total of these two components being at least 90% of the total esterified estrogens content.
Esterified estrogens are used to treat conditions related to estrogen deficiency and moderate to severe vasomotor menopausal symptoms in women. They are also used for hormone replacement therapy and treatment of osteoporosis.
Q: What is the mechanism of action of esterified estrogens?
A: Esterified estrogens act by binding to nuclear receptors in estrogen-responsive tissues. They modulate the pituitary secretion of gonadotropins (LH and FSH) through a negative feedback mechanism, reducing the elevated levels of these hormones seen in postmenopausal women.
Q: How are esterified estrogens absorbed and distributed in the body?
A: Esterified estrogens are readily absorbed after oral administration. They are widely distributed in the body, with higher concentrations found in sex hormone target organs. In the blood, they circulate largely bound to sex hormone binding globulin (SHBG) and albumin.
Q: What are the potential side effects or risks associated with esterified estrogens?
A: Esterified estrogens may increase the risk of certain cancers, including breast and endometrial cancer. They may also increase the risk of cardiovascular events such as stroke and blood clots. Use of esterified estrogens should be carefully considered and monitored by a healthcare professional.
Company Name | Contact Information |
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SYMBIOTEC PHARMALAB PRIVATE LTD | Tel: 91 731 4200052 Email: [email protected] |
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