Cinobufotalin (CAS 1108-68-5) Suppliers and Product Information

Cinobufotalin is a cardioactive steroid of the bufadienolide class that acts as a specific Na /K ATPase inhibitor. It is less active than ouabain in its inhibitory effects. Cinobufotalin has diverse biological activities, including diuretic and hemostatic properties, and can stimulate cytotoxic effects in cultured lung cancer cells.

Cinobufotalin is used as a standard to calibrate high-performance liquid chromatography (HPLC) and calculate the total quantity of bufadienolides present in the nuchal gland fluid of Rhabdophis tigrinus. It has applications in various fields, including medicine, health care products, cosmetics, nutritional supplements, and food additives.

Frequently Asked Questions about Cinobufotalin

Q: What are the main applications of Cinobufotalin?

A: Cinobufotalin has various applications, including:

• Treatment of middle and advanced tumors (lung cancer, breast cancer, cervical cancer, digestive system tumors)
• Management of chronic hepatitis B, especially for chronic hepatitis B virus carriers
• Use as a diuretic and hemostatic agent
• Research purposes in studying Na /K ATPase inhibition

Q: What are the potential side effects of Cinobufotalin?

A: Some potential side effects of Cinobufotalin include:

• Chills and fever (if dosage is too large or administration intervals are too short)
• Local irritation or phlebitis after long-term intravenous infusion
• Rare cases of urticaria or dermatitis

Q: How should Cinobufotalin be stored?

A: Cinobufotalin should be stored at 4°C to maintain its stability and efficacy.