PEMIROLAST (CAS 69372-19-6) Suppliers and Product Information

PEMIROLAST is an anti-allergic inhibitor used to prevent the release of inflammatory mediators. It is primarily used topically in the eye to prevent itching associated with allergic conjunctivitis. The compound has also shown potential in preventing restenosis after percutaneous coronary angioplasty.

PEMIROLAST is synthesized through a multi-step process involving the reaction of 3-methylpyridine with sodium in liquid ammonia, followed by several intermediate steps to form the final product. The potassium salt is prepared by reacting the free acid form with potassium hydroxide.

Frequently Asked Questions about PEMIROLAST

Q: What is the main use of PEMIROLAST?

A: PEMIROLAST is primarily used as a topical treatment in the eye to prevent itching associated with allergic conjunctivitis. It acts as an inhibitor of the release of histamine and other inflammatory mediators, including leukotrienes.

Q: Is PEMIROLAST used systemically?

A: While PEMIROLAST is mainly used topically, significant use as a systemic agent has been reported. It has shown value in preventing restenosis after percutaneous coronary angioplasty.

Q: What is the chemical classification of PEMIROLAST?

A: PEMIROLAST is classified as a pyridopyrimidine compound. It contains an acidic tetrazole group, which serves as an isosteric replacement for a carboxylic acid functionality.

Q: Are there any alternative names for PEMIROLAST?

A: Yes, PEMIROLAST is also known by several synonyms, including Pemiroplast, Pemilaston, and its chemical name 9-Methyl-3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one.