Amsacrine (CAS 51264-14-3) Suppliers and Product Information

Amsacrine is an aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent. It is primarily used in the treatment of acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL), particularly in cases where other treatments have failed. Amsacrine is also known by other names such as m-AMSA, AMSA, and CI-880.

Chemical Properties: - Melting point: 230-240°C - Boiling point: 563.0-60.0°C - Predicted density: 1.2205 g/cm³ - Solubility: Soluble in DMSO - Form: Powder - Color: Orange to red

Storage: Store at 2-8°C and protect from light.

Safety Information: - Hazard Class: 6.1(b) - Packing Group: III - Toxicity: LD50 in male/female CDF1 mice: 810 mg/m², 729 mg/m² orally

Frequently Asked Questions about Amsacrine

Q: What is the primary use of Amsacrine? A: Amsacrine is primarily used as an antineoplastic agent for the treatment of acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL), especially in cases where other treatments have failed.

Q: How does Amsacrine work? A: Amsacrine is a cytotoxic drug that binds to DNA with specificity to the adenosine-tyrosine pair, inhibiting DNA synthesis. It acts as a topoisomerase II poison, interfering with the enzyme's ability to repair DNA breaks.

Q: Are there any significant side effects associated with Amsacrine? A: Yes, the clinical use of Amsacrine is associated with significant neurotoxicity, gastrotoxicity, and hepatotoxicity.

Q: Is Amsacrine approved for general use? A: Amsacrine is considered an investigational drug, undergoing intensive trials for severe leukemia and lymphoma. It is not approved for general use in all countries.