Procaine Hydrochloride (CAS 51-05-8) Suppliers and Product Information

Procaine hydrochloride is a local anesthetic of the amino ester group, primarily used as a topical anesthetic. It's also known as Novocain or Novocaine. It can block nerve fiber conduction temporarily and has a *** effect with strong efficacy, low toxicity, and is non-addictive. However, it has weak penetration on skin and mucosa, making it unsuitable for surface anesthesia. It's commonly used for infiltration, conduction, and spinal anesthesia.

Frequently Asked Questions about Procaine Hydrochloride

What is the mechanism of action of procaine hydrochloride?

Procaine hydrochloride acts as a sodium channel blocker. It binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of nerve impulses. This action increases the electrical excitation threshold, reduces the rate of action potential rise, and slows nerve impulse propagation, resulting in local anesthesia.

What are the main clinical applications of procaine hydrochloride?

Procaine hydrochloride is primarily used for: - Local anesthesia in dentistry - Infiltration anesthesia - Nerve block anesthesia - Peridural and spinal anesthesia - Pain control during intramuscular injection of penicillin

What precautions should be taken when using procaine hydrochloride?

While procaine hydrochloride is considered relatively safe, the following precautions should be observed: - Slow administration and avoidance of accidental intravenous injection - Initial small dose to test tolerance in patients with suspected increased sensitivity (e.g., those with cardiac disease or endocrine disorders like hyperthyroidism) - Careful monitoring for idiosyncratic reactions - Proper storage and handling to prevent oxidation and discoloration